膜タンパク質(英語表記:Membrane protein)


膜タンパク質とは、
細胞などの生体膜に付着しているタンパク質分子である。

構造と活性を保ち大量精製し丸ごと水に溶かし出すことが非常に難しい。

βバレルは、他にミトコンドリアや葉緑体の外膜にのみ見られる。

膜タンパク質の役割として、情報伝達、エネルギー合成が挙げられる。
膜と相互作用を持つタンパク質はグラミシジンのようにイオノフォアとしてイオンに膜を通過させたりする。
膜タンパク質の役割としては、外界からの物質の取り込みや排出が挙げられる。

細胞は核やミトコンドリアなどの細胞内小器官もリン脂質膜で囲まれている。
構造が中々解明されなかった理由として、分析機器、例えばX線、電子線、放射光、NMRなどが不十分であった。

以下は、膜たんぱく質技術2012の実施場所、詳細などの記録です。
Implementation site of membrane protein technology 2012, the following is a record of such details.

Welcome to Membrane Protein Technologies 2012!
November 28-30, 2012
Westin Hotel, San Francisco

This Meeting will be hosted by the Membrane Protein Expression Center, one of the centers funded by the NIH Common Fund Structural Biology Program, organized by Dr. Robert Stroud, UCSF.

REGISTRATION IS NOW OFFICIALLY CLOSED

Information About Workshops

DAY 1:
Wednesday, November 28th
8:00am | On site check in
9:00 am | Meeting begins
12:30 pm | Lunch
7:00 pm | Conference Dinner

DAY 2:
Thursday, November 29th
9:00 am-6:30pm | Meeting

DAY 3:
Friday, November 30th
8:30 am-12:00 noon | Meeting
12:00 noon | Conference ends

About

The 4th NIH Roadmap meeting to Membrane Protein Structures and Complexes will be held at the San Francisco Westin Hotel in downtown San Francisco on Wednesday November 28th 2012, 8:00 AM through Friday, November 30th, noon. This Meeting will be hosted by the Membrane Protein Expression Center, one of the centers funded by the NIH Common Fund Structural Biology Program, organized by Dr. Robert Stroud, UCSF.

This series of meetings have been very successful in generating open exchange and sharing of technologies, materials, and ideas focused on targeting membrane protein structure determination. This 4th meeting in the series provides a unique opportunity for all investigators engaged in developing and applying new technologies for structural biology of membrane proteins and complexes to focus on technologies that facilitate membrane protein structure determination, and recent structures of membrane proteins. This meeting will include all investigators supported by the NIH common fund program for structural biology, and invites all PSI member membrane protein groups, and all investigators of membrane protein structure to participate fully.

Presentations and discussions chosen from submitted abstracts will focus on progress as well as overcoming barriers that could transform functional expression of membrane proteins and complexes, and structure determination at atomic resolution. Corporate participation is encouraged for those companies who are actively working on membrane protein targets, and those producing equipment and reagents for membrane protein research. Corporate involvement in abstract submission, presentations or display for the meeting is encouraged.

Industry participation is encouraged for companies who are actively working on membrane protein targets, or producing equipment and reagents for membrane protein research. Meeting sponsorships for industry partners are available.

新着情報

  • 研究内容を更新。(2014.9.11)
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  • 研究員1名追加。(2014.4.1)
  • ウェブサイトを更新。(2014.1.14)